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Background
Bisphenol A is widely used in the manufacture of polycarbonate plastics and has caused increasing concern over its potential adverse impacts on spermatogenesis. However, the effect of bisphenol A on spermiogenesis is yet to be explored.
Objectives
To evaluate whether bisphenol A has adverse effects on DNA integrity and protamination of spermatogenic cell.
Materials and methods
Newborn...
Background
Type 5 phosphodiesterase (PDE5) expression in the normal and pathological prostate is controversial.
Objectives
This study aimed at identifying the cell type/s, if any, expressing PDE5 in human healthy or pathological prostate sections in order to further validate the rationale of PDE5 inhibitor (PDE5i) treatment of benign prostatic hyperplasia (BPH) and their safety in the treatment...
Background
Concerns exist about the effect of delaying treatment for prostate cancer (PCa) regarding both oncological and functional outcomes after radical prostatectomy (RP).
Objective
To assess the impact of time from diagnosis to RP on post‐operative erectile function (EF) outcomes.
Materials and methods
We analyzed data for 827 patients treated with RP at a single center from 2002 to 2017...
Background
Capacitation is not a well‐defined process, required for the acrosome reaction triggered by physiological stimuli. In vitro, capacitation is achieved by sperm incubation in artificial media supplemented with HCO3−, Ca2+, and albumin. The role of capacitation in the membrane fusion machinery required for acrosomal exocytosis is not well‐known. SNARE proteins are fundamental for intracellular...
Objectives
The aim of the study was to investigate the ability of the systemic inflammatory parameters to predict the discrimination of the phases of Peyronie's disease (PD).
Materials and methods
Demographic, clinical, and laboratory data from 156 patients with PD were analyzed. A complete blood count (CBC) was obtained for every patient, and the neutrophil‐to‐lymphocyte ratio (NLR), platelet‐to‐lymphocyte...
Background
Male infertility is a global health issue caused by a combination of different factors. Specialists generally rely on semen analysis to diagnose male infertility. However, it is known that diagnostic semen analysis fails to identify about 50% of male infertility disorders. Recently, metabolomics has been proven to be a powerful technique for the diagnosis of different diseases.
Objective...
Introduction
Hyperactivity of the sympathetic nervous system was considered as one of the factors involved in the pathological mechanisms of premature ejaculation (PE). Sympathetic skin response of the penis (PSSR) was used to evaluate the activity of sympathetic innervations in the penis, which was controlled by the central nervous system (brain). Shorter PSSR was found in PE patients; however,...
Background
Myo‐inositol (cis‐1,2,3,5‐trans‐4,6‐cyclohexanehexol; MI) is the most prominent of nine inositol stereoisomers. MI, its phosphate derivatives, and associated lipids are widely found in vegetables and animal tissues and are known to participate in numerous biological processes.
Objectives
To perform a review analysis on MI presence, functions, and impact in male fertility.
Materials...
Background
Fertility in men with hypospadias may be affected due to anatomical, surgical, or etiological factors and associated conditions. Fertility is further influenced by psychosocial and genetic factors, often shared within families.
Objective
To evaluate fertility in men born with hypospadias and assess confounding by familial factors.
Materials and methods
A population‐based cohort of...
Background
Codeine is the latest trend of drug abuse, particularly in Nigeria and regarded as the gateway to the abuse of other substances.
Objectives
The present study examined the effects of graded doses of codeine on sexual behaviour and fertility profile.
Materials and methods
Rabbits were either administered normal saline (0.2 mL), 4mg/kg b.w of codeine (low dose), or 10mg/kg b.w of codeine...
Background
Erectile dysfunction (ED) is a common complication in patients with diabetes mellitus (DM) that severely affects the patients' quality of life. However, the effectiveness of oral phosphodiesterase type 5 inhibitors in these patients is poor. Sphingosine‐1‐phosphate (S1P) and S1P receptor 2 (S1PR2) are important factors regulating the Rho‑kinase pathway, and understanding these factors...
Background
Oxidative stress (OS) is one of the most prevalent causes of sperm damage, through the toxic effects of endogenously generated hydrogen peroxide, superoxide anion, and hydroxyl radicals. Peripheral leukocytes represent a feasible model for studying the pathophysiology of OS‐mediated homeostasis, which can be responsible for cell dysfunction and cell injury.
Objective
To evaluate the...
Introduction
Recent neuroimaging studies have indicated that some brain areas are involved in the sexual behavior process. Pre‐mature ejaculation patients exhibit altered brain activation and abnormal cortical structures. However, there has been no research evaluating the topological organization of structural brain network in anejaculation (AE).
Methods
We employed diffusion tensor imaging data...
Introduction
Human brain was a complex network of interconnected regions. Recent neuroimaging studies had showed that the disruption of brain connectivity was associated with psychological disorders. Abnormal rich club and robustness of brain networks might have a key role in the pathophysiology of psychogenic erectile dysfunction (pED).
Methods
Both diffusion and functional magnetic resonance...
Background
The most common type of male infertility is asthenospermia. We cloned DnaJ heat shock protein family member B13 (Dnajb13/DNAJB13), a type II HSP40 family member that is highly expressed in the testis. DNAJB13 plays a crucial role in sperm flagellar function.
Objectives
The aim of this study was to investigate whether a correlation exists between DNAJB13 and low sperm motility in infertile...
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